Why do only 66 of 806 SIX3 target genes show expression changes in Asxl1-deficient cells?

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Priority

77%

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75%

Tractability

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Description

Despite identifying 806 direct SIX3 targets, only 8% show concordant expression changes when ASXL1 is lost. This selectivity suggests unknown factors determine which SIX3 targets require ASXL1 for proper regulation, limiting our understanding of the partnership’s specificity.

Gap type: unexplained_observation Source paper: Loss of Asxl1 disrupts telencephalic midline integrity through dysregulation of SIX3 target genes. (None, None, PMID:40393104)

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