What is the molecular mechanism by which ASXL1-SIX3 interaction regulates chromatin state at target genes?

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Description

The study shows ASXL1 directly interacts with SIX3 and they co-regulate target genes, but the chromatin-level mechanism is unexplained. Understanding this epigenetic regulatory mechanism is crucial for developing therapeutic approaches for holoprosencephaly and related brain malformations.

Gap type: unexplained_observation Source paper: Loss of Asxl1 disrupts telencephalic midline integrity through dysregulation of SIX3 target genes. (None, None, PMID:40393104)

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