Why does AKT1 upregulation correlate with suppressed autophagy when AKT1 typically promotes autophagy?

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The study shows AKT1 upregulation alongside decreased LC3B and Beclin1, suggesting autophagy suppression. This contradicts established knowledge that AKT1 generally promotes autophagy initiation. Understanding this paradox is crucial for interpreting environmental toxicant effects on cellular homeostasis.

Gap type: contradiction Source paper: Methyl-4-hydroxybenzoate induces osteoporosis via the AKT1/LC3B/Beclin1 autophagy signaling pathway: Integrating network toxicology and experimental validation. (2026, Ecotoxicology and environmental safety, PMID:41740552)

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