What determines TFAM's selectivity for cytoplasmic versus mitochondrial mtDNA binding?

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Description

TFAM normally functions within mitochondria but this study reveals it binds cytoplasmic mtDNA as an autophagy receptor. The molecular mechanisms governing this compartment-specific functional switch are unknown, yet critical for understanding mitochondrial quality control.

Gap type: unexplained_observation Source paper: TFAM is an autophagy receptor that limits inflammation by binding to cytoplasmic mitochondrial DNA. (2024, Nat Cell Biol, PMID:38783142)

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