What molecular mechanisms trigger activity-dependent, nonapoptotic caspase-3 activation at presynapses?

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Description

The study shows that increased neuronal activity triggers localized presynaptic caspase-3 activation, but the upstream signaling pathways and molecular triggers remain unexplained. Understanding this mechanism is crucial for developing targeted interventions to modulate synaptic pruning in neurological disorders.

Gap type: unexplained_observation Source paper: Nonapoptotic caspase-3 guides C1q-dependent synaptic phagocytosis by microglia. (None, None, PMID:39843445)

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