How does caspase-3 activation facilitate complement tagging at synapses without triggering apoptosis?

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Description

The abstract reveals that caspase-3 promotes complement tagging for microglial phagocytosis while avoiding cell death, contradicting the established role of caspase-3 as an apoptotic executioner. This mechanistic gap is critical for understanding non-canonical caspase functions in synaptic remodeling.

Gap type: contradiction Source paper: Nonapoptotic caspase-3 guides C1q-dependent synaptic phagocytosis by microglia. (None, None, PMID:39843445)

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