What mechanisms link SWI/SNF mutations to neurodevelopmental disorders versus cancer phenotypes?

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Description

The abstract notes that SWI/SNF mutations cause both cancer and neurodevelopmental disorders, but doesn’t explain why the same genetic defects produce such divergent phenotypes. Understanding this mechanistic divergence is critical for developing tissue-specific therapeutic approaches.

Gap type: unexplained_observation Source paper: Chromatin remodellers as therapeutic targets. (2024, Nature reviews. Drug discovery, PMID:39014081)

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