How do SCFA and BHB mechanistically coordinate neuroprotection across different neurodegenerative diseases?

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Description

While the abstract identifies these metabolites as key mediators, the specific mechanisms linking gut-derived metabolites to disease-specific neuroprotection remain unexplained. Understanding this could reveal common therapeutic targets.

Gap type: unexplained_observation Source paper: Intermittent Fasting as a Neuroprotective Strategy: Gut-Brain Axis Modulation and Metabolic Reprogramming in Neurodegenerative Disorders. (2025, Nutrients, PMID:40732891)

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