What is the molecular mechanism linking cysteine oxidation to reduced protein mobility in proteolethargy?

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Description

The abstract identifies cysteine residues and ROS as linked to proteolethargy but doesn’t explain the mechanistic connection. Understanding this mechanism is critical since cysteine oxidation is implicated in neurodegeneration and could represent a therapeutic target.

Gap type: unexplained_observation Source paper: Proteolethargy is a pathogenic mechanism in chronic disease. (None, None, PMID:39610243)

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