What specific mechanisms link mTOR hyperactivation to disrupted autophagy, neural organization, and neurotransmitter pathways in ASD?

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Description

The abstract identifies mTOR hyperactivation as disrupting multiple cellular processes but doesn’t explain the mechanistic connections between mTOR signaling and these diverse downstream effects. Understanding these pathways is critical for targeted therapeutic development.

Gap type: unexplained_observation Source paper: mTOR signaling pathway as a pathophysiologic mechanism in preclinical models of autism spectrum disorder. (None, None, PMID:39481829)

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