How do findings from preclinical mTOR-related ASD models translate to clinical populations and therapeutic outcomes?

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Description

While the review claims to bridge preclinical models with clinical data, the abstract doesn’t address how well animal model findings predict human ASD pathophysiology or treatment responses. This translation gap is crucial for clinical application of mTOR-targeted therapies.

Gap type: open_question Source paper: mTOR signaling pathway as a pathophysiologic mechanism in preclinical models of autism spectrum disorder. (None, None, PMID:39481829)

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