How does BYHWD selectively modulate cAMP/PKA/CREB pathway components given its multi-compound nature?

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Description

The study demonstrates BYHWD affects cAMP/PKA/CREB signaling but doesn’t explain which specific compounds in this complex herbal formula target which pathway components. This mechanistic gap limits rational drug development and dosing optimization.

Gap type: unexplained_observation Source paper: Buyang huanwu decoction improves synaptic plasticity of ischemic stroke by regulating the cAMP/PKA/CREB pathway. (None, None, PMID:39089658)

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