How does the S209F mutation alter ABI3 phosphorylation and what are the functional consequences?

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Description

The authors demonstrate that the AD-associated S209F variant changes ABI3 phosphorylation patterns in vitro, but the specific phosphorylation sites affected and how this altered phosphorylation translates to disease risk remain unknown. This gap limits understanding of how genetic variants mechanistically contribute to AD susceptibility.

Gap type: unexplained_observation Source paper: Deletion of Abi3/Gngt2 influences age-progressive amyloid β and tau pathologies in distinctive ways. (2022, Alzheimer’s research & therapy, PMID:35897046)

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