How should multi-targeted ASO approaches be designed to address AD's multifactorial pathology?

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Priority

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70%

Market price

50%

Description

The abstract suggests AD requires multi-targeted approaches and that ASOs can utilize different posttranscriptional mechanisms, but doesn’t specify how to optimally combine targets or mechanisms. This gap limits rational therapeutic design.

Gap type: open_question Source paper: Antisense oligonucleotides for Alzheimer’s disease therapy: from the mRNA to miRNA paradigm. (2021, EBioMedicine, PMID:34773891)

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