How do different tryptophan metabolites selectively activate AhR signaling in brain microvessels versus other tissues?

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Description

The abstract notes that brain microvessels have enriched AhR expression and are targets of tryptophan metabolites, but doesn’t explain the tissue-specific mechanisms of AhR activation. This selectivity could be key to understanding why the gut-brain axis specifically affects cerebrovascular function in AD.

Gap type: unexplained_observation Source paper: Activation of aryl hydrocarbon receptor (AhR) in Alzheimer’s disease: role of tryptophan metabolites generated by gut host-microbiota. (2023, J Mol Med (Berl), PMID:36757399)

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