What specific FOXO4 target genes mediate the restoration of synaptic plasticity in depression?

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Description

While the study demonstrates FOXO4 nuclear translocation restores synaptic plasticity, the downstream transcriptional targets responsible for this effect remain unidentified. Understanding these specific gene targets is crucial for developing more precise therapeutic interventions for depression-related synaptic dysfunction.

Gap type: unexplained_observation Source paper: Wenyang-Tianjing-Jieyu decoction ameliorates Kidney-Yang deficiency type depression-like behavior in Sprague-Dawley rats by enhancing neurogenesis via the FOXO signaling pathway. (2026, Journal of ethnopharmacology, PMID:41475623)

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