How do canonical and non-canonical TGFβ pathway modulations coordinate to drive neurogenic effects?

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Description

The study reports that NVP-13 modulates both canonical TGFβ and non-canonical pathways (MAPK, PI3K), but doesn’t explain how these parallel pathway changes integrate to produce the observed neurogenic outcomes. This mechanistic understanding is essential for predicting off-target effects and optimizing treatment specificity.

Gap type: unexplained_observation Source paper: Reconditioning the Neurogenic Niche of Adult Non-human Primates by Antisense Oligonucleotide-Mediated Attenuation of TGFβ Signaling. (2021, Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, PMID:33860461)

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