What molecular mechanisms determine the male-specific vulnerability to cadmium-induced cognitive deficits?

developmental neurotoxicology open
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Description

The study shows clear sex-specific effects with only male offspring developing cognitive deficits, but the underlying molecular basis for this gender specificity remains unexplained. Understanding these mechanisms is critical for developing targeted interventions and identifying at-risk populations.

Gap type: unexplained_observation Source paper: PLCβ4 driven by cadmium-exposure during gestation and lactation contributes to cognitive deficits by suppressing PIP2/PLCγ1/CREB/BDNF signaling pathway in male offspring. (None, None, PMID:38820747)

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