How can machine learning algorithms reliably distinguish CTE from Alzheimer's tau patterns in PET imaging?

neuroimaging open
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Description

The authors suggest machine learning could differentiate tau accumulation patterns between CTE and Alzheimer’s disease, but specific algorithmic approaches and validation methods remain undefined. This represents a critical technical gap for ante mortem CTE diagnosis.

Gap type: open_question Source paper: The diagnostic potential of fluid and imaging biomarkers in chronic traumatic encephalopathy (CTE). (2022, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, PMID:35062068)

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