How do Gap43 upregulation and mTOR activation mechanistically link to cholinergic pathway disruption?

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Description

The authors identify disrupted cholinergic signaling as the primary neurotoxic mechanism and suggest Gap43/mTOR involvement, but the mechanistic connection between these pathways remains unexplained. Understanding this link is crucial for predicting neurodevelopmental impacts of environmental pollutants.

Gap type: unexplained_observation Source paper: The synergistic effects of UV-328 and polystyrene microplastics on zebrafish embryos: developmental toxicity, oxidative stress, and neurotoxicity. (2026, Aquat Toxicol, PMID:41771220)

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