What biological mechanisms underlie the gene expression patterns that predict disease-gene associations?

neurogenetics open
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Description

While GADO successfully uses expression data to predict gene-phenotype relationships, the fundamental biological basis for why co-expression patterns reflect disease causality remains unclear. This mechanistic gap limits our understanding of how genetic networks contribute to neurological phenotypes.

Gap type: unexplained_observation Source paper: Improving the diagnostic yield of exome- sequencing by predicting gene-phenotype associations using large-scale gene expression analysis. (2019, Nature communications, PMID:31253775)

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