Does MLKL contribute to neuroinflammation through necroptosis-independent mechanisms?

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Description

The authors note that MLKL’s role in neuroinflammation remains unclear despite being the final necroptosis executor. The anti-inflammatory effects of MLKL inhibition suggest functions beyond cell death execution that warrant investigation for therapeutic development.

Gap type: open_question Source paper: Anti-inflammatory mechanism of the MLKL inhibitor necrosulfonamide in LPS- or poly(I:C)-induced neuroinflammation and necroptosis. (2025, Biochemical pharmacology, PMID:40473224)

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