How do astrocytes coordinate their dual roles in neurovascular coupling and synaptic homeostasis during AD progression?

neurovascular biology open
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Description

The abstract highlights astrocyte functions in both cerebral blood flow regulation and tripartite synapse maintenance, but the mechanistic integration of these roles remains unclear. This coordination likely becomes dysregulated in AD, representing a potential therapeutic target.

Gap type: unexplained_observation Source paper: Emerging Roles of Astrocytes in Neuro-Vascular Unit and the Tripartite Synapse With Emphasis on Reactive Gliosis in the Context of Alzheimer’s Disease. (2018, Frontiers in cellular neuroscience, PMID:30042661)

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