How does the rs12506228 variant mechanistically link reduced MT1 receptors to impaired early cognitive development?

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Description

The authors suggest the risk allele connects to fewer brain MT1 melatonin receptors and slower socioemotional/communication development, but the mechanistic pathway is unexplained. Understanding this could reveal how melatonin signaling influences early neurodevelopment and potentially inform interventions.

Gap type: unexplained_observation Source paper: Variation near MTNR1A associates with early development and interacts with seasons. (None, None, PMID:31588999)

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