What is the developmental trajectory linking early cognitive delays to later Alzheimer's disease risk via MTNR1A?

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Description

The same variant associates with both slower infant development and adult Alzheimer’s disease, suggesting a lifelong developmental trajectory. The connection between early cognitive delays and later neurodegeneration risk through melatonin signaling remains unexplored but could reveal critical windows for intervention.

Gap type: open_question Source paper: Variation near MTNR1A associates with early development and interacts with seasons. (None, None, PMID:31588999)

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