How does MS4A6A mechanistically regulate the disease-associated microglia (DAM) response in Alzheimer's disease?

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Description

MS4A6A knockdown reduced DAM cluster proportions under all conditions, suggesting it modulates this critical AD-relevant microglial state. However, the specific molecular mechanisms by which MS4A6A controls DAM activation and maintenance remain unexplained.

Gap type: unexplained_observation Source paper: High throughput identification of genetic regulators of microglial inflammatory processes in Alzheimer’s disease. (2025, Journal of neuroinflammation, PMID:41340152)

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