Why do plasma p-tau217 and tau-PET show equivalent predictive performance despite measuring different aspects of tau pathology?

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Description

The study shows plasma p-tau217 (systemic tau phosphorylation) and tau-PET (regional brain tau aggregation) have nearly identical predictive power for cognitive decline. The biological mechanisms explaining this equivalence between peripheral and central tau measures are unclear, which limits understanding of tau pathophysiology progression.

Gap type: unexplained_observation Source paper: Plasma p-tau217 and tau-PET predict future cognitive decline among cognitively unimpaired individuals: implications for clinical trials. (2025, Nature aging, PMID:40155777)

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