How does electroacupuncture specifically activate the CD38-cADPR-Ca2+ pathway to trigger mitochondrial transfer?

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Description

The study identifies CD38-cADPR-Ca2+ signaling as involved in electroacupuncture-mediated mitochondrial transfer but doesn’t explain the mechanistic link between acupuncture stimulation and this pathway activation. Understanding this connection is crucial for optimizing therapeutic protocols and identifying the minimal effective stimulation parameters.

Gap type: unexplained_observation Source paper: Mechanisms of electroacupuncture-induced neuroprotection in acute stroke rats: the role of astrocyte-mediated mitochondrial transfer. (2025, Cell communication and signaling : CCS, PMID:40598228)

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