What determines the directionality and selectivity of astrocyte-to-neuron mitochondrial transfer?

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Description

While the study demonstrates enhanced mitochondrial transfer from astrocytes to neurons, it doesn’t explain what molecular signals determine transfer direction or how astrocytes selectively target damaged versus healthy neurons. This mechanistic gap limits understanding of how to enhance therapeutic specificity.

Gap type: unexplained_observation Source paper: Mechanisms of electroacupuncture-induced neuroprotection in acute stroke rats: the role of astrocyte-mediated mitochondrial transfer. (2025, Cell communication and signaling : CCS, PMID:40598228)

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