Why do tau-targeting therapies fail clinically despite tau's stronger correlation with cognitive decline than Aβ?

neurodegeneration open
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Description

The abstract reveals a paradox: tau levels correlate more strongly with cognitive impairment than Aβ depositions, yet tau-targeting therapies have consistently failed to show clinical benefit while Aβ antibodies are achieving FDA approval. This contradiction suggests fundamental gaps in understanding tau’s role or therapeutic targeting strategies.

Gap type: contradiction Source paper: Anti-amyloid-β Antibodies and Anti-tau Therapies for Alzheimer’s Disease: Recent Advances and Perspectives. (2024, Chemical & pharmaceutical bulletin, PMID:38945936)

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