How do mitochondrial fusion/fission dynamics, biogenesis, and mitophagy differentially contribute to osteoporosis pathogenesis?

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Description

While the abstract mentions that mitochondrial fusion/fission, biogenesis, and mitophagy are involved in osteoporosis pathology, the relative contributions and interactions between these distinct mitochondrial quality control processes are not mechanistically defined. This knowledge gap limits the ability to prioritize therapeutic targets within mitochondrial quality control pathways.

Gap type: open_question Source paper: Mitochondrial quality control and its role in osteoporosis. (2023, Frontiers in endocrinology, PMID:36793284)

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