Does the CaMKII/CaN switch mechanism operate in axon regeneration after injury?

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Description

The findings demonstrate this calcium switch in developmental pathfinding, but whether the same mechanism controls regenerating axons in mature nervous systems is unknown. This gap is critical for translating developmental guidance mechanisms to therapeutic axon regeneration strategies.

Gap type: open_question Source paper: A CaMKII/calcineurin switch controls the direction of Ca(2+)-dependent growth cone guidance. (2004, Neuron, PMID:15363394)

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