Why is SLC45A1 neuron-specific when other lysosomal proteins show broader cell-type distribution?

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Description

The study reveals SLC45A1 as uniquely neuron-specific among lysosomal proteins, contrasting with the typical broader distribution of lysosomal components. This cell-type restriction may explain the neurological specificity of SLC45A1-associated disease but the underlying mechanism is unclear.

Gap type: unexplained_observation Source paper: Cell-Type Resolved Protein Atlas of Brain Lysosomes Identifies SLC45A1-Associated Disease as a Lysosomal Disorder. (2024, bioRxiv : the preprint server for biology, PMID:39464040)

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