How do Aβ oligomers specifically target synapses while sparing other cellular structures?

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Description

The abstract describes that Aβ oligomers ‘specifically target synapses’ but doesn’t explain the selectivity mechanism. This specificity is crucial for understanding why cognitive deficits occur early in AD and could inform synapse-protective therapeutic strategies.

Gap type: unexplained_observation Source paper: Synaptic changes in Alzheimer’s disease and its models. (2013, Neuroscience, PMID:22687952)

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