How does nucleolin contribute to Alzheimer's disease pathology at the molecular level?

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Description

While nucleolin is described as involved in Alzheimer’s disease pathology, the specific molecular mechanisms linking this histone chaperone to neurodegeneration are not explained. This gap limits understanding of nucleolin as a potential therapeutic target in AD.

Gap type: unexplained_observation Source paper: Functions of the histone chaperone nucleolin in diseases. (2007, Subcell Biochem, PMID:17484127)

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