What mechanisms drive nucleolin's translocation from nucleus to cell surface in cancer cells?

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Description

The abstract notes nucleolin appears on cancer cell surfaces but doesn’t explain how this nuclear protein translocates or what triggers this pathological redistribution. Understanding this mechanism could reveal therapeutic targets for cancer treatment.

Gap type: unexplained_observation Source paper: Functions of the histone chaperone nucleolin in diseases. (2007, Subcell Biochem, PMID:17484127)

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