What determines the temporal sequence between AMPK inhibition and mitochondrial dynamics disruption?

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Description

The study shows both AMPK signaling disruption and abnormal mitochondrial fusion/fission, but the causal relationship and timing between these events is not established. Clarifying this sequence could identify the primary therapeutic target for intervention.

Gap type: unexplained_observation Source paper: Aconitine induces mitochondrial energy metabolism dysfunction through inhibition of AMPK signaling and interference with mitochondrial dynamics in SH-SY5Y cells. (2021, Toxicology letters, PMID:33945864)

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