Why is CXCL10 specifically predictive of CPSP risk compared to other inflammatory markers?

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Description

The study identifies CXCL10 as having excellent predictive accuracy for CPSP (AUC=0.90), but doesn’t explain why this particular chemokine is superior to other inflammatory biomarkers. Understanding this specificity could reveal unique pathophysiological pathways in chronic pain development.

Gap type: unexplained_observation Source paper: Early repetitive transcranial magnetic stimulation for preventing chronic postoperative pain in older adults: a randomized clinical sub-study. (2026, BMC Med, PMID:41943114)

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