Why does hippuric acid show higher affinity for GPR109A versus GPR109B despite structural similarities?

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Description

The computational analysis reveals differential binding affinities between the two receptor subtypes, but the structural basis for this selectivity is not mechanistically explained. This selectivity could be key for designing specific therapeutic interventions targeting bone metabolism.

Gap type: unexplained_observation Source paper: Exploring GPR109A Receptor Interaction with Hippuric Acid Using MD Simulations and CD Spectroscopy. (None, None, PMID:36499106)

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