What molecular mechanisms mediate Mertk-interferon-β synergy in blood-brain barrier protection?

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Description

The abstract describes synergistic effects between Mertk activation and interferon-β in tightening endothelial junctions, but the underlying signaling pathways are not explained. Understanding this crosstalk is crucial for developing BBB-protective therapies.

Gap type: unexplained_observation Source paper: The TAM receptor Mertk protects against neuroinvasive viral infection by maintaining blood-brain barrier integrity. (2015, Nature medicine, PMID:26523970)

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