What molecular mechanisms drive T217 phosphorylation in MAPT R406W carriers without amyloid pathology?

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Description

The study shows MAPT R406W mutation increases tau T217 phosphorylation despite normal amyloid levels, contradicting the established view that pT217 is primarily linked to amyloidosis. Understanding this amyloid-independent pathway could reveal new therapeutic targets for tauopathies.

Gap type: contradiction Source paper: MAPT R406W increases tau T217 phosphorylation in absence of amyloid pathology. (2021, Annals of clinical and translational neurology, PMID:34342183)

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