Why do exercise-responsive pathways differ between neurons and peripheral tissues?

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Description

The study found that putative exerkines remained unchanged in NDEVs despite exercise, while neuroprotective proteins increased, suggesting distinct exercise-responsive pathways in neurons versus peripheral tissues. This mechanistic divergence is unexplained but could reveal tissue-specific therapeutic targets.

Gap type: unexplained_observation Source paper: Neuron-derived extracellular vesicles in blood reveal effects of exercise in Alzheimer’s disease. (2023, Alzheimer’s research & therapy, PMID:37730689)

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