What molecular mechanisms drive the temporal switch from microglial to astroglial activation during tau pathology progression?

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Description

The study shows microglia target early tau pathology while astrocytes engage later coincident with neuronal death, but the mechanistic basis for this temporal coordination is unexplained. Understanding this switch could reveal critical intervention windows for neuroinflammation modulation.

Gap type: unexplained_observation Source paper: Temporal progression of tau pathology and neuroinflammation in a rhesus monkey model of Alzheimer’s disease. (2024, Alzheimer’s & dementia : the journal of the Alzheimer’s Association, PMID:39030748)

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