Can immunomodulatory therapies effectively target neuroinflammation in familial FTD?

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Description

The authors suggest neuroinflammation warrants consideration of immunomodulatory therapies but provide no evidence for therapeutic efficacy. This represents a critical translational gap for disease modification strategies.

Gap type: open_question Source paper: In vivo PET imaging of neuroinflammation in familial frontotemporal dementia. (2021, Journal of neurology, neurosurgery, and psychiatry, PMID:33122395)

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