What molecular mechanisms drive monocyte-to-microglia transformation and long-term persistence in injured brain?

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Description

The study shows CCR2+ monocytes become Tmem119+ Sall1+ P2RY12+ ramified microglia persisting for months after neonatal injury, but the signaling pathways controlling this phenotypic transformation are not explained. Understanding these mechanisms is critical for determining whether monocyte-derived microglia retain pathological functions long-term.

Gap type: unexplained_observation Source paper: Monocytes promote acute neuroinflammation and become pathological microglia in neonatal hypoxic-ischemic brain injury. (2022, Theranostics, PMID:34976198)

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