How does Reelin signaling transition from developmental neuronal layering to postdevelopmental synaptic modulation?

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Description

The abstract describes distinct developmental versus postdevelopmental functions of Reelin but doesn’t explain how the same signaling pathway mediates such different cellular processes. This mechanistic gap limits understanding of how developmental proteins acquire homeostatic functions.

Gap type: unexplained_observation Source paper: Reelin: Neurodevelopmental Architect and Homeostatic Regulator of Excitatory Synapses. (2017, The Journal of biological chemistry, PMID:27994051)

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