What are the specific molecular mechanisms linking tau dysfunction to glucose homeostasis alterations?

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Description

The abstract states that links between tau impairments and glucose homeostasis remain unclear, despite evidence that tau loss contributes to glucose alterations in AD. Understanding these mechanisms is critical for determining whether metabolic dysfunction is a cause or consequence of tau pathology.

Gap type: open_question Source paper: Impaired Glucose Homeostasis in a Tau Knock-In Mouse Model. (None, None, PMID:35250480)

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