Why does dietary treatment for PKU remain inadequate despite decades of use and refinement?

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Description

The abstract states that dietary treatment has ‘significant shortcomings’ but doesn’t explain the underlying mechanisms causing treatment failure. Understanding these limitations is critical for developing better therapeutic approaches and optimizing gene therapy strategies.

Gap type: unexplained_observation Source paper: State-of-the-art 2023 on gene therapy for phenylketonuria. (None, None, PMID:37401651)

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