Why does sTREM2 mediation vary substantially between P-tau (20-25%) and T-tau (36-44%) for BIN1 variants?

neurodegeneration open
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Description

The mediation analysis shows sTREM2 explains nearly twice as much of the BIN1-T-tau relationship compared to BIN1-P-tau, suggesting different pathways may be involved. This differential mediation pattern could reveal distinct mechanisms by which neuroinflammation affects tau processing versus tau phosphorylation.

Gap type: unexplained_observation Source paper: sTREM2 Mediates the Correlation Between BIN1 Gene Polymorphism and Tau Pathology in Alzheimer’s Disease. (2024, Journal of Alzheimer’s disease : JAD, PMID:39240638)

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