How does complement-mediated synaptic pruning specifically affect glutamatergic versus other neuron types in depression?

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Description

The study shows XYS1 preserves glutamatergic neuron density and excitatory synapses while inhibiting complement-mediated pruning, but the selectivity for glutamatergic circuits is not mechanistically explained. This specificity could reveal key pathways in depression pathophysiology.

Gap type: unexplained_observation Source paper: Panacis Quinquefolii Radix Polysaccharides Alleviate Depressive-Like Behaviors in Chronic Unpredictable Mild Stress-Induced Mice by Suppressing Complement C1Q/C3-Mediated Microglial Synaptic Pruning and Modulating Gut Microbiota. (2026, CNS neuroscience & therapeutics, PMID:41914021)

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